1.承担项目: 主持国家自然科学基金项目1项,陕西省科技厅项目1项,西安市科协青年托举项目1项,陕西科技大学科研启动项目1项,横向项目1项,部分如下: [1] 国家自然科学基金青年基金:基于蛋白晕策略的纳米靶向载体的构建及其跨胃肠屏障作用机制的研究 [2]陕西省科学技术厅项目:基于蛋白质组学手段的靶向纳米粒克服胃肠道粘液屏障的分子机制研究 [3]西安市科学技术协会青年人才托举计划:可调控性蛋白包被对口服主动靶向纳米载体转运效率的影响研究 2.科研成果 先后发表SCI学术论文20多篇,申请国内外专利多项(授权3项)。部分以第一/通讯作者发表论文、第一发明人申请/授权专利如下: 1.Protein coronas derived from mucus act as both spear and shield to regulate transferrin functionalized nanoparticle transcellular transport in enterocytes, ACS Nano, 2024, doi: 10.1021/acsnano.3c11315.(IF 17.1) 2.Recent advances in bioactive nanocrystal-stabilized Pickering emulsions: Fabrication, characterization, and biological assessment. Comprehensive Reviews in Food Science and Food Safety 2023, 22(2)946-970.(IF 14.8) 3.Proton-Gradient-Driven Porphyrin-Based Liposome Remote-Loadedwith Imiquimod as In Situ Nanoadjuvants for Synergistically Augmented Tumor Photoimmunotherapy. ACS Applied Materials & Interfaces, 2024, 16, 8403-8416.(IF 9.5) 4.Construction, characterization and bioactivity evaluation of curcumin nanocrystals with extremely high solubility and dispersion prepared by ultrasound-assisted method, Ultrasonics Sonochemistry, 2024, Accept.(IF 8.4) 5.Physicochemical stability of Pickering emulsion stabilized with spherical and fibrous iron ions loaded whey protein isolate/gum Arabic complexes. Food Hydrocolloids 2023, 138, 108471-108481.(IF 10.7) 6.Transferrin functionization elevates transcytosis of nanogranules across epithelium by triggering polarity-associated transport flow and positive cellular feedback loop. ACS Nano. 2019, 13, 5058-5076.(IF 17.1) 7.The preparation and application of gold nano-materials in biodiagnostics, imaging, drug delivery and combination therapy. Asian Journal of Pharmaceutical Sciences. 2019, 10, 349-364.(IF10.2) 8.United States Patent, 授权, Patent No.:11117859 B1 9.一种包载 Toll 样受体激动剂的脂质体组合物纳米佐剂及其制备方法,申请号:202311767991.1 10.一种活性分子纳米晶功能饮料添加物及其制备方法和应用,申请号:202311803074.4 11.一种蛋白预包被主动靶向纳米载体及其制备方法和应用,申请号:202311253880.9 3.获奖 1. 第九届“我最喜欢的导师”称号 2. 指导学生获得陕西科技大学2021年,2022年优秀本科毕业论文
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