主要承担项目及成果 | 1.承担项目 [1] 国家自然科学基金青年项目:球毛壳菌中提高猕猴桃抗细菌性溃疡病的物质基础及其作用机制研究,2022.12-2025.12,主持。 [2] 陕西省科技厅重点研发项目:新型抗猕猴桃细菌性溃疡病生物源农药的研究与开发,2024.1-2025.12,主持。 [3] 陕西省中医药管理局项目:古代经典名方达原饮的开发研究,2022.10-2024.9,主持。 [4] 陕西省科技厅一般项目:基于CDC25A靶点的泽漆中抗肿瘤药效物质及作用机制研究,2018.1-2020.12,主持。 [5] 横向项目:具有广谱抗菌活性的天然产物化合物库的构建研究,2022.11-2024.11,主持。 2.论文/论著(在 Journal of Medicinal Chemistry,European Journal of Medicinal Chemistry,Organic Letters 等发表论文10余篇,部分论文如下) [1] Min Li*, Jialin Li, Jingyi Li, et al, Qianqian Zhao*, Hong Gao, Chengyuan Liang*. Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria. European Journal of Medicinal Chemistry, 2023, 259(5): 115653-115674. [2] Qianqian Zhao, Wenjun Wei, Ya Li, et al. Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases. Natural Product Research, 2022, 36(3): 754-759. [3] Qianqian Zhao, Liang Xin, Yuzhi Liu, et al. Current Landscape and Future Perspective of Oxazolidinone Scaffolds Containing Antibacterial Drugs. Journal of Medicinal Chemistry, 2021, 64(15): 10557-10580. [4] Qianqian Zhao, Qiuyan Song, Kan Jiang, et al. Spirochensilides A and B, Two New Rearranged Triterpenoids from Abies chensiensis. Organic Letters, 2015, 17(11): 2760-2763. [5] 赵倩倩, 张少军, 等. 五味子茎叶的化学成分研究. 中草药, 2021, 52(23): 7111-7116. [6] 赵倩倩*, 肖琴,苗宇, 等. 秦岭冷杉茎叶的化学成分研究.中草药, 2020, 51(6): 1491-1497. 3.专利(授权国际专利5项,国内专利1项,部分专利如下) [1] Qianqian Zhao, Jialin Li, Dan Yang, et al. Sypringa pubescens microphylla seed extract composition and its application in antibiotic-resistant infections[P], US 11,712,457 B2. [2] Qianqian Zhao, Jie Zhang, Liang Xin, et al. Pleuromutilin (phenylthio)acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same[P]. US 11,518,740 B2. [3] Qianqian Zhao, Liang Xin, Jingyi Li, et al. Pleuromutilin salicylic acid ester with antibacterialactivity and a method of preparing the same[P]. US 11,401,233 B1. |