1.代表性科研项目(主持) 主持国家级、省部级、厅局级等多项科研项目,部分代表性项目如下: (1)国家自然科学基金:基于靶标ssDNA现场扩增与数字化编码策略的肉类掺假纳米孔多重检测技术研究 (2)陕西省科技厅项目:陕西特色小杂粮加工过程中品质及质量安全检测研究 (3)陕西省教育厅项目:基于CRISPR/Cas12a串联纳米孔道单分子指纹系统的多重肉类掺假现场检测技术研究 (4)西安市科技局项目:基于核酸适配体串联纳米孔道单分子指纹系统的真菌毒素多重便携检测技术研究 2.代表性论文(第一/通讯作者) 在国际顶级期刊发表了多篇高水平论文,涵盖纳米孔技术在食品真实性检测、生物传感器开发等领域的应用。部分代表性论文包括: (1)Size-tunable transmembrane nanopores assembled from decomposable molecular templates, Biosensors & Bioelectronics , 2025, 267, 116780 (一区Top期刊,IF 10.7) (2)Simultaneous high-resolution detection of bioenergetic molecules using biomimetic-receptor nanopore, Analytical Chemistry, 2019, 91, 15255-15259(一区Top期刊,IF 6.8) (3)An aptamer-triggered hybridization chain reaction strategy for ultra-sensitive biological nanopore detection of aflatoxin B1, Sensors and Actuators B: Chemical, 2024, 407, 135457(一区Top期刊,IF 8.0) (4)A clickase-mediated immunoassay based on nanopore and bionic signal labels for ultrasensitive, portable, and on-site detection of ricin, Journal of Agricultural and Food Chemistry, 2024, 72, 25330–25339(一区Top期刊,封面文章,IF 5.7) (5)Nanopore-based biomimetic ssDNA reporters for multiplexed detection of meat adulteration, Journal of Agricultural and Food Chemistry, 2024, 72, 25357–25366(一区Top期刊,IF 5.7) (6)Nanopore-assisted ELISA platform for ultrasensitive, portable, and on-site detection of ricin, Talanta, 2025, 283, 127136 (一区Top期刊,IF 5.6) (7)Recent progress on single-molecule detection technologies for food safety, Journal of Agricultural and Food Chemistry, 2022, 70, 458-469(一区Top期刊,IF 6.1) (8)An aptamer-assisted biological nanopore biosensor for ultra-sensitive detection of ochratoxin A with a portable single-molecule measuring instrument, Talanta, 2022, 248, 123619(一区Top期刊,IF 6.1) (9)Low background interference SERS aptasensor for highly sensitive multiplex mycotoxin detection based on polystyrene microspheres-mediated controlled release of Raman reporters, Analytica Chimica Acta, 2022, 1218, 340000(一区Top期刊,IF 6.2) (10) A nanopore-based label-free CRISPR/Cas12a system for portable and ultrasensitive detection of zearalenone, Analytica Chimica Acta, 2024, 1330, 343280(一区Top期刊,IF 5.7) 3.专利及软件著作权 拥有多项专利及软件著作权,涵盖单分子检测仪器的设计与开发: (1)一种生物纳米孔道的微弱电流放大电路,申请号:CN202111015400.6 (2)一种基于纳米孔的单分子便携式检测装置,申请号:CN202111520139.5 (3)检测仪器(纳米孔单分子检测仪器),专利号:ZL202330029971.9 (4)纳米孔单分子检测数据分析与可视化软件,登记号: 2023SR0935057 (5)Nanopore Recorder纳米孔微弱电流采集与控制软件,登记号: 2023SR0934968 5.获奖 (1)陕西省第六届研究生创新成果展省级一等奖(2022,第一指导教师) (2)陕西省第七届研究生创新成果展省级C档(2023,第一指导教师)。 (3)陕西科技大学校级优秀毕业设计(论文)(2023,指导教师) 6.招生信息 欢迎对学习和实践感兴趣的同学加入实验室!无论你是否具备科研经验或明确的方向,这里都为你提供充分的支持和良好的条件,帮助你培养解决问题的能力,探索新知识,并逐步找到适合自己的兴趣点和发展方向。实验室注重实践与成长,同时鼓励培养批判性思维,希望每位加入的同学都能在轻松融洽的环境中不断进步,挑战自我,拓展视野。 |